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Bohemian Trastevere is one of Rome’s most historic and picturesque neighborhoods—a maze of cobbled streets lined with enticing restaurants, fashionable sidewalk cafés, and lively bars. Across the river from the center of Rome (hence the area's name, which means “across the Tiber”), it's home to Piazza Santa Maria in Trastevere, the site of one of Rome’s oldest churches (from AD 340) and a majestic 15th-century fountain. Other neighborhood sights include the beautiful Santa Cecilia in Trastevere church, dating from the 5th century, and Villa Farnesina, filled with stunning frescoes—including two attributed to Raphael.