Begin by getting to know Florence's most famous landmark from top to bottom: the Florence Duomo. Tackle this popular sight first thing to beat the crowds, and book a tour with skip-the-line access to avoid spending the bulk of your morning waiting to enter the church, baptistery, bell tower, dome, and museum.

Following Florence's famous architecture, it's time to move on to its impressive art. Join a combo tour that visits both the Uffizi and Accademia galleries to touch on the highlights of both these museums without feeling overwhelmed. Skip-the-line tours are a must for these attractions, which draw millions of visitors each year.

You've had an intense day of culture, so now unwind while sampling some of the excellent wines produced in the Chianti hills outside of Florence—perhaps paired with some of the region's cheeses, meats, and olive oils—during a food or wine-tasting tour.

Now that you've crossed the Duomo, Uffizi, and Accademia off your list, explore the sights of Florence's city center from the Ponte Vecchio and Piazza della Signoria to the quiet lanes of the Oltrarno. Hop-on hop-off bus tours are a perfect way to get an overview of the city, while guided walking, biking, and Segway tours offer up-close experiences.

Dive deep into Florence's traditional cuisine by learning how to prepare some of its most famous dishes during a cooking class. Discover the secret to making pasta, pizza, and other specialties, and then enjoy the fruits of your labor during an informal meal at the end of the class.

You will soon say goodbye to Florence, so make your final evening special by watching the sun set over the city. Book an Arno river cruise or head to the Piazzale Michelangelo on foot, bike, or hop-on hop-off bus tour to watch the sun set over the water.