Construction of Genoa's cathedral began in the early 11th century, though the facade and interiors weren’t completed until centuries later under Perugian architect Galeazzo Alessi. As a result, the architecture blends Romanesque, Gothic, and mannerist elements. Inside, the cathedral is decorated with sumptuous 14th-century frescoes and is home to the chalice said to have been used by Christ during the Last Supper (displayed in the Treasury Museum beneath the cathedral).
San Lorenzo Cathedral is a popular stop on hop-on hop-off or private walking or scooter tours, along with the Palazzi dei Rolli, Palace of the Doges, and Old Port. Tours of Genoa’s historic center can be paired with day trips to the nearby coastal villages of Santa Margherita Ligure, Portofino, and the Cinque Terre.