Built for two Medici cardinals who later became popes Leo X and Clement VII, Palazzo Madama saw a series of regal residents—from Catherine de’ Medici to Cardinal Francesco Maria Del Monte, best known as patron of Caravaggio—before housing Italy’s Senate in the 19th century. Today, many of its halls retain original Renaissance flourishes, primarily ceiling coffers and frescoes. Later renovations modernized the remainder of the lavish interior, and much of the art dates from the Risorgimento, Italy’s unification.
You can visit the palace only with a guide—tours are available on the first Saturday of the month on a first-come-first-serve basis. Many walking, e-bike, and Vespa tours of Rome’s famous sights go past the palace.