This southern Italian capital reigns the Mezzogiorno region like mercurial royalty: bold, theatrical, and full of life. One of the oldest cities in Europe, Naples is a treasury of art, architecture, and archaeology, from the catacombs beneath the historic center (a UNESCO World Heritage Site) to palazzi-turned-museums and baroque and rococo artworks stockpiled in chapels throughout. If you run out of things to do in Naples, you can sojourn to the dazzling Amalfi Coast, ferry to the islands in the bay, or walk among miraculously preserved ruins in Pompeii. But before you go, try the pizza—the city's top claim to fame.