The Piccolomini Library was built in the 1400s by Pope Pius III to house the manuscripts of his uncle, Enea Silvio Piccolomini, who was also Pope Pius II. Most of the manuscripts never made it here, and instead you can view its extraordinary frescoes, painted by Pinturicchio between 1503 and 1508 and depicting important stages of the life of Pope Pius II.
You can best appreciate the frescoes in the Piccolomini library on a guided tour of the Siena duomo complex, including skip-the-line tickets to the Piccolomini Library, along with the cathedral, crypt, baptistry (Battistero di San Giovanni), and Museo dell'Opera. The cathedral complex is a highlight of Siena’s historic center and is included on many walking tours or on day trips from Florence to Siena, Pisa, and San Gimignano.