Alessandro Farnese commissioned Palazzo Farnese in the 16th century, and the building was expanded to its current size after he became Pope Paul III in 1534, with adornments like Michelangelo’s ornate central window that served as the facade’s focal point and dramatic backdrop for the pope’s public appearances overlooking Piazza Farnese. Today visitors can admire the palazzo’s ornate interiors including Sangallo’s atrium, the Carracci Gallery, and the Hercules salon with tapestries inspired by Raffaello’s frescos, and the courtyard and garden.
Palace visits are only by guided tour on Monday, Wednesday, and Friday and must be booked at least a week ahead of time. View the palace from the outside on a walking, e-bike, or Vespa Rome highlights tour that includes sights such as the Quirinale Palace, Piazza Navona, Campo de’ Fiori, and the Spanish Steps. Sightseeing tours can easily be combined with skip-the-line tickets to the Colosseum and Vatican Museums.