Tiber Island is situated in the Tiber River in Rome, just south of the Centro Storico between the former Jewish ghetto on the east bank and Trastevere on the west bank. There are two historic pedestrian bridges that connect the island to the river banks: Ponte Cestio and Ponte Fabricio, one of the oldest bridges in the city. The island, which has had a strong connection with medicine since antiquity, is where ailing Romans were often sent for treatment or quarantine. Today, one of Rome's main hospitals is still located here, as is the historic Church of San Bartolomeo all'Isola.
Tiber Island is often included in Rome walking or Segway tours that cover the Jewish ghetto or Trastevere. You can also explore the island during a hop-on-hop-off river cruise, a bus tour of Rome highlights (including the Sistine Chapel and St. Peter's Basilica in the Vatican), or a private tour that’s paired with the Basilica of St. Nicholas, whose underground excavations have uncovered ancient Roman temples dating back to the 5th century BC.