Siena’s Pinacoteca Nazionale has been housed in the late Gothic Palazzo Buonsignori since 1932. Its collection includes works from the late medieval through the Renaissance periods, including paintings from members of the Sienese School, among them Duccio di Buoninsegna, Simone Martini, and the Lorenzetti brothers. In the 1970s, the Spannocchi-Piccolomini Collection was added, which focuses on Northern and Flemish artists such as Durer.
Pair a visit to the museum, near the main Piazza del Campo, with a walking tour of Siena’s historic center, including its magnificent Duomo complex. Siena is a popular stop on day trips to and from Florence and Rome that also stop in Pisa or the medieval villages of San Gimignano, Monteriggioni, and Castellina. Full-day sightseeing itineraries in Tuscany generally include a stop for lunch and wine tasting.