Housed in the baroque 17th-century Palazzo di Brera, the Pinacoteca di Brera has grand interiors and a lovely neoclassical cloister, and a visit to its stellar collection is a must for any art enthusiast. The museum's headliner is The Lamentation of Christ by Andrea Mantegna, a Mannerist gem. The surrounding Brera district, a charming maze of narrow, cobblestone streets lined with boutiques and cafés near the Duomo in the city center, is one of the trendiest neighborhoods in Milan. Join a walking tour of Brera that includes skip-the-line tickets to the Pinacoteca di Brera to explore both the neighborhood and its most famous attraction. Brera is also a great place to experience Milan’s excellent food and wine scene, so consider joining a small-group food walking tour that has a gastronomic bent.