One of the charms of picturesque Lake Orta is the tiny island at its center, Isola San Giulio, home to a centuries-old basilica and monastery. Ferries run to the island from the medieval village of Orta San Giulio, whose historical center and 16th-century town hall are worth exploring; climb the hill above town to visit the Sacro Monte chapels. A few small towns dot the shores of the lake, including Pettenasco and Omegna, but this isn't the tourist-centered experience of Lake Garda or Lake Como.
Lake Orta is a popular excursion from Milan or Stresa, and joining a Lake Orta day trip by coach is an easy way to experience the lake without the hassle of driving. Alternatively, consider taking a private tour of Orta San Giulio and San Giulio Island to get the most out of these out-of-the-way spots.