Founded at the end of the Hundred Years’ War by Nicolas Rolin—the chancellor of Burgundy—the Hospices de Beaune is considered one of the region’s finest cultural attractions. In addition to its distinctive Flemish-inspired architecture, the building’s Grande Salle and museum collection (featuring paintings, tapestries, and other medieval treasures) are popular with history geeks and art connoisseurs—don’t miss Rogier van der Weyden’s The Beaune Altarpiece. The Hospices de Beaune is also a wine destination, with 148 acres (60 hectares) of vineyards with pinot noir and chardonnay grapes. Every year, a wine auction takes place on the third Sunday of November. Wine tours of Burgundy and guided biking excursions typically stop by the Hospices de Beaune.